The Democrat Hillary Clinton's plan for Syria would "lead to World War III," said the Republican presidential nominee Donald Trump.

Trump said in an interview focused largely on foreign policy, that, defeating Islamic State is a higher priority than persuading Syrian President Bashar al-Assad to step down, playing down a long-held goal of US policy.

"Assad is secondary, to me, to ISIS," he said.

"What we should do is focus on ISIS. We should not be focusing on Syria," said Trump. "You're going to end up in World War III over Syria if we listen to Hillary Clinton.”

"You're not fighting Syria any more, you're fighting Syria, Russia and Iran, all right? Russia is a nuclear country, but a country where the nukes work as opposed to other countries that talk," he said.

Clinton spokesman Jesse Lehrich said in a statement, that, "Once again, he is parroting Putin's talking points and playing to Americans' fears, all while refusing to lay out any plans of his own for defeating ISIS or alleviating humanitarian suffering in Syria."

Regarding the Republican unity,  he said, "If we had party unity, we couldn't lose this election to Hillary Clinton." "The people are very angry with the leadership of this party, because this is an election that we will win 100 percent if we had support from the top. I think we're going to win it anyway."

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